Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

Caspase-1 drives a lytic inflammatory cell death named pyroptosis by cleaving the pore-forming cell death executor gasdermin-D (GSDMD). Gsdmd deficiency, however, only delays cell lysis, indicating that caspase-1 controls alternative cell death pathways. Here, we show that in the absence of GSDMD, c...

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Vydáno v:Life Sci Alliance
Hlavní autoři: Heilig, Rosalie, Dilucca, Marisa, Boucher, Dave, Chen, Kaiwen W, Hancz, Dora, Demarco, Benjamin, Shkarina, Kateryna, Broz, Petr
Médium: Artigo
Jazyk:Inglês
Vydáno: Life Science Alliance LLC 2020
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7190276/
https://ncbi.nlm.nih.gov/pubmed/32345661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000735
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