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Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly
Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase‐1, caspase‐4, caspase‐5 and caspase‐11. These caspases cleave and activate the pore‐forming protein gasdermin D (GSDMD) to induce membrane damage. By contrast, apoptosis is driven by apoptotic caspase‐8 or caspase‐9...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6517827/ https://ncbi.nlm.nih.gov/pubmed/30902848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101638 |
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