Extrinsic and intrinsic apoptosis activate pannexin‐1 to drive NLRP3 inflammasome assembly

Pyroptosis is a form of lytic inflammatory cell death driven by inflammatory caspase‐1, caspase‐4, caspase‐5 and caspase‐11. These caspases cleave and activate the pore‐forming protein gasdermin D (GSDMD) to induce membrane damage. By contrast, apoptosis is driven by apoptotic caspase‐8 or caspase‐9...

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Publicat a:EMBO J
Autors principals: Chen, Kaiwen W, Demarco, Benjamin, Heilig, Rosalie, Shkarina, Kateryna, Boettcher, Andreas, Farady, Christopher J, Pelczar, Pawel, Broz, Petr
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6517827/
https://ncbi.nlm.nih.gov/pubmed/30902848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019101638
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