The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity

Inflammasomes activate the protease caspase-1, which cleaves interleukin-1β and interleukin-18 to generate the mature cytokines and controls their secretion and a form of inflammatory cell death called pyroptosis. By generating mice expressing enzymatically inactive caspase-1(C284A), we provide gene...

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Vydáno v:Cell Rep
Hlavní autoři: Schneider, Katharina S., Groß, Christina J., Dreier, Roland F., Saller, Benedikt S., Mishra, Ritu, Gorka, Oliver, Heilig, Rosalie, Meunier, Etienne, Dick, Mathias S., Ćiković, Tamara, Sodenkamp, Jan, Médard, Guillaume, Naumann, Ronald, Ruland, Jürgen, Kuster, Bernhard, Broz, Petr, Groß, Olaf
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750195/
https://ncbi.nlm.nih.gov/pubmed/29281832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.12.018
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