Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis

The BH3-only protein Bid is known as a critical mediator of the mitochondrial pathway of apoptosis following death receptor activation. However, since full-length Bid possesses potent apoptotic activity, the role of a caspase-mediated Bid cleavage is not established in vivo. In addition, due to the...

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Библиографические подробности
Опубликовано в: :J Biol Chem
Главные авторы: Huang, Kai, Zhang, Jingjing, O'Neill, Katelyn L., Gurumurthy, Channabasavaiah B., Quadros, Rolen M., Tu, Yaping, Luo, Xu
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Cell Biology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4882451/
https://ncbi.nlm.nih.gov/pubmed/27053107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.711051
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