Fatal Hepatitis Mediated by TNFα Requires Caspase-8 and Involves the BH3-only Proteins Bid and Bim

Apoptotic death of hepatocytes, a feature and contributing factor of many chronic and acute liver diseases, can be a consequence of over-activation of the immune system. Injection with lipopolysaccharide (LPS) plus the transcriptional inhibitor D(+)-galactosamine (GalN) or mitogenic T cell activatio...

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Main Authors: Kaufmann, Thomas, Jost, Philipp J, Pellegrini, Marc, Puthalakath, Hamsa, Gugasyan, Raffi, Gerondakis, Steve, Cretney, Erika, Smyth, Mark J, Silke, John, Hakem, Razq, Bouillet, Philippe, Mak, Tak W, Dixit, Vishva M, Strasser, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938743/
https://ncbi.nlm.nih.gov/pubmed/19119023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.10.017
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