Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein

The BH3-only protein Bim is a critical initiator of apoptosis in hematopoietic cells. Bim is upregulated in response to growth factor withdrawal and in vitro studies have implicated the transcription factor Foxo3a as a critical inducer. To test the importance of this regulation in vivo, we generated...

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Detalhes bibliográficos
Main Authors: Herold, Marco J, Rohrbeck, Leona, Lang, Mathias J, Grumont, Raelene, Gerondakis, Steve, Tai, Lin, Bouillet, Philippe, Kaufmann, Thomas, Strasser, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3818073/
https://ncbi.nlm.nih.gov/pubmed/24060902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.152
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