Alternative splicing of Bim and Erk-mediated Bim(EL) phosphorylation are dispensable for hematopoietic homeostasis in vivo

The pro-apoptotic BH3-only protein Bim has a major role in hematopoietic homeostasis, particularly in the lymphocyte compartment, where it strongly affects immune function. The three major Bim isoforms (Bim(EL), Bim(L) and Bim(S)) are generated by alternative splicing. Bim(EL), the most abundant iso...

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Detalhes bibliográficos
Main Authors: Clybouw, C, Merino, D, Nebl, T, Masson, F, Robati, M, O'Reilly, L, Hübner, A, Davis, R J, Strasser, A, Bouillet, P
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354058/
https://ncbi.nlm.nih.gov/pubmed/22240894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.198
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