Loss of Bim Increases T Cell Production and Function in Interleukin 7 Receptor–deficient Mice

Interleukin (IL)-7 receptor (R) signaling is essential for T and B lymphopoiesis by promoting proliferation, differentiation, and survival of cells. Mice lacking either IL-7 or the IL-7Rα chain have abnormally low numbers of immature as well as mature T and B lymphocytes. Transgenic expression of th...

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Autores principales: Pellegrini, Marc, Bouillet, Philippe, Robati, Mikara, Belz, Gabrielle T., Davey, Gayle M., Strasser, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2004
Materias:
Brief Definitive Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211860/
https://ncbi.nlm.nih.gov/pubmed/15504823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041328
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