cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

Three members of the IAP family (X-linked inhibitor of apoptosis (XIAP), cellular inhibitor of apoptosis proteins-1/-2 (cIAP1 and cIAP2)) are potent suppressors of apoptosis. Recent studies have shown that cIAP1 and cIAP2, unlike XIAP, are not direct caspase inhibitors, but block apoptosis by functi...

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Bibliographic Details
Main Authors: Vanlangenakker, N, Vanden Berghe, T, Bogaert, P, Laukens, B, Zobel, K, Deshayes, K, Vucic, D, Fulda, S, Vandenabeele, P, Bertrand, M J M
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2011
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131911/
https://ncbi.nlm.nih.gov/pubmed/21052097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2010.138
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