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Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

We describe a generic approach to assemble correctly two heavy and two light chains, derived from two existing antibodies, to form human bivalent bispecific IgG antibodies without use of artificial linkers. Based on the knobs-into-holes technology that enables heterodimerization of the heavy chains,...

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Bibliografski detalji
Glavni autori: Schaefer, Wolfgang, Regula, Jörg T., Bähner, Monika, Schanzer, Jürgen, Croasdale, Rebecca, Dürr, Harald, Gassner, Christian, Georges, Guy, Kettenberger, Hubert, Imhof-Jung, Sabine, Schwaiger, Manfred, Stubenrauch, Kay G., Sustmann, Claudio, Thomas, Markus, Scheuer, Werner, Klein, Christian
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131342/
https://ncbi.nlm.nih.gov/pubmed/21690412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019002108
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