Učitavanje...
Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
We describe a generic approach to assemble correctly two heavy and two light chains, derived from two existing antibodies, to form human bivalent bispecific IgG antibodies without use of artificial linkers. Based on the knobs-into-holes technology that enables heterodimerization of the heavy chains,...
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Glavni autori: | , , , , , , , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
National Academy of Sciences
2011
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Teme: | |
Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3131342/ https://ncbi.nlm.nih.gov/pubmed/21690412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019002108 |
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