Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies

The development of bispecific antibodies has attracted substantial interest, and many different formats have been described. Those specifically containing an Fc part are mostly tetravalent, such as stabilized IgG-scFv fusions or dual-variable domain (DVD) IgGs. However, although they exhibit IgG-lik...

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Bibliografiske detaljer
Main Authors: Klein, Christian, Sustmann, Claudio, Thomas, Markus, Stubenrauch, Kay, Croasdale, Rebecca, Schanzer, Jürgen, Brinkmann, Ulrich, Kettenberger, Hubert, Regula, Jörg T., Schaefer, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Review
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3502232/
https://ncbi.nlm.nih.gov/pubmed/22925968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.21379
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