Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies

We describe a generic approach to assemble correctly two heavy and two light chains, derived from two existing antibodies, to form human bivalent bispecific IgG antibodies without use of artificial linkers. Based on the knobs-into-holes technology that enables heterodimerization of the heavy chains,...

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Detalhes bibliográficos
Main Authors: Schaefer, Wolfgang, Regula, Jörg T., Bähner, Monika, Schanzer, Jürgen, Croasdale, Rebecca, Dürr, Harald, Gassner, Christian, Georges, Guy, Kettenberger, Hubert, Imhof-Jung, Sabine, Schwaiger, Manfred, Stubenrauch, Kay G., Sustmann, Claudio, Thomas, Markus, Scheuer, Werner, Klein, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3131342/
https://ncbi.nlm.nih.gov/pubmed/21690412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1019002108
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