DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

High specificity accompanied with the ability to recruit immune cells has made recombinant therapeutic antibodies an integral part of drug development. Here we present a generic approach to generate two novel IgG-derived antibody formats that are based on a modification of the CrossMab technology. M...

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Vydáno v:MAbs
Hlavní autoři: Sustmann, Claudio, Dickopf, Steffen, Regula, Jörg T., Kettenberger, Hubert, Mølhøj, Michael, Gassner, Christian, Weininger, Diana, Fenn, Sebastian, Manigold, Tobias, Kling, Lothar, Künkele, Klaus-Peter, Schwaiger, Manfred, Bossenmaier, Birgit, Griese, Julia J., Hopfner, Karl-Peter, Graff-Meyer, Alexandra, Stahlberg, Henning, Ringler, Philippe, Lauer, Matthias E., Brinkmann, Ulrich, Schaefer, Wolfgang, Klein, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816436/
https://ncbi.nlm.nih.gov/pubmed/31526159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2019.1661736
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