TriFabs—Trivalent IgG-Shaped Bispecific Antibody Derivatives: Design, Generation, Characterization and Application for Targeted Payload Delivery

TriFabs are IgG-shaped bispecific antibodies (bsAbs) composed of two regular Fab arms fused via flexible linker peptides to one asymmetric third Fab-sized binding module. This third module replaces the IgG Fc region and is composed of the variable region of the heavy chain (VH) fused to CH3 with “kn...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Mayer, Klaus, Baumann, Anna-Lena, Grote, Michael, Seeber, Stefan, Kettenberger, Hubert, Breuer, Sebastian, Killian, Tobias, Schäfer, Wolfgang, Brinkmann, Ulrich
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661895/
https://ncbi.nlm.nih.gov/pubmed/26593903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms161126037
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