Anti-tumoral, anti-angiogenic and anti-metastatic efficacy of a tetravalent bispecific antibody (TAvi6) targeting VEGF-A and angiopoietin-2

Vascular endothelial growth factor (VEGF)-A blockade has been validated clinically as a treatment for human cancers. Angiopoietin-2 (Ang-2) is a key regulator of blood vessel remodeling and maturation. In tumors, Ang-2 is up-regulated and an unfavorable prognostic factor. Recent data demonstrated th...

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Veröffentlicht in:MAbs
Hauptverfasser: Scheuer, Werner, Thomas, Markus, Hanke, Petra, Sam, Johannes, Osl, Franz, Weininger, Diana, Baehner, Monika, Seeber, Stefan, Kettenberger, Hubert, Schanzer, Jürgen, Brinkmann, Ulrich, Weidner, K. Michael, Regula, Jörg, Klein, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2016
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Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966847/
https://ncbi.nlm.nih.gov/pubmed/26864324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1147640
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