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DOT1L, the H3K79 methyltransferase, is required for MLL-AF9–mediated leukemogenesis

Chromosomal translocations of the mixed lineage leukemia (MLL) gene are a common cause of acute leukemias. The oncogenic function of MLL fusion proteins is, in part, mediated through aberrant activation of Hoxa genes and Meis1, among others. Here we demonstrate using a tamoxifen-inducible Cre-mediat...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nguyen, Anh Tram, Taranova, Olena, He, Jin, Zhang, Yi
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2011
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128482/
https://ncbi.nlm.nih.gov/pubmed/21521783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-334359
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