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DOT1L, the H3K79 methyltransferase, is required for MLL-AF9–mediated leukemogenesis
Chromosomal translocations of the mixed lineage leukemia (MLL) gene are a common cause of acute leukemias. The oncogenic function of MLL fusion proteins is, in part, mediated through aberrant activation of Hoxa genes and Meis1, among others. Here we demonstrate using a tamoxifen-inducible Cre-mediat...
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| Glavni autori: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128482/ https://ncbi.nlm.nih.gov/pubmed/21521783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-334359 |
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