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Bioelectronic Delivery of Electrons to Cytochrome P450 Enzymes

Cytochrome P450s (cyt P450s) are the major oxidative enzymes in human oxidative metabolism of drugs and xenobiotic chemicals. In nature, the iron heme cyt P450s utilize oxygen and electrons delivered from NADPH by a reductase enzyme to oxidize substrates stereo- and regioselectively. Significant res...

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Bibliografiske detaljer
Main Authors: Krishnan, Sadagopan, Schenkman, John B., Rusling, James F.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128182/
https://ncbi.nlm.nih.gov/pubmed/21591685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp201235m
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