Electrochemiluminescent Arrays for Cytochrome P450-Activated Genotoxicity Screening. DNA Damage from Benzo[a]pyrene Metabolites

Arrays suitable for genotoxicity screening are reported that generate metabolites from cytochrome P450 enzymes (CYPs) in thin-film spots. Array spots containing DNA, various human cyt P450s, and electrochemiluminescence (ECL) generating metallopolymer [Ru(bpy)(2)PVP(10)](2+) were exposed to H(2)O(2)...

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Autori principali: Hvastkovs, Eli G., So, Minjeong, Krishnan, Sadagopan, Bajrami, Besnik, Tarun, Maricar, Jansson, Ingela, Schenkman, John B., Rusling, James F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2323608/
https://ncbi.nlm.nih.gov/pubmed/17261025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac061975q
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