Human cyt P450 mediated metabolic toxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) evaluated using electrochemiluminescent arrays

Electrochemiluminescent (ECL) arrays containing polymer ([Ru(bpy)(2)(PVP)(10)](2+), PVP = polyvinylpyridine), DNA, and selected enzymes were employed to elucidate cytochrome (cyt) P450 dependent metabolism of the tobacco specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Bioa...

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Bibliographic Details
Main Authors: Krishnan, Sadagopan, Hvastkovs, Eli G., Bajrami, Besnik, Schenkman, John B., Rusling, James F.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3481181/
https://ncbi.nlm.nih.gov/pubmed/19156262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b815910f
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