Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

BACKGROUND: The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were mea...

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Hauptverfasser: Dow, Geoffrey S, Milner, Erin, Bathurst, Ian, Bhonsle, Jayendra, Caridha, Diana, Gardner, Sean, Gerena, Lucia, Kozar, Michael, Lanteri, Charlotte, Mannila, Anne, McCalmont, William, Moon, Jay, Read, Kevin D, Norval, Suzanne, Roncal, Norma, Shackleford, David M, Sousa, Jason, Steuten, Jessica, White, Karen L, Zeng, Qiang, Charman, Susan A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128011/
https://ncbi.nlm.nih.gov/pubmed/21645370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-10-150
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