Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols

BACKGROUND: The clinical utility for mefloquine has been eroded due to its association with adverse neurological effects. Better-tolerated alternatives are required. The objective of the present study was the identification of lead compounds that are as effective as mefloquine, but exhibit physioche...

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Main Authors: Milner, Erin, McCalmont, William, Bhonsle, Jayendra, Caridha, Diana, Cobar, Jose, Gardner, Sean, Gerena, Lucia, Goodine, Duane, Lanteri, Charlotte, Melendez, Victor, Roncal, Norma, Sousa, Jason, Wipf, Peter, Dow, Geoffrey Stuart
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833169/
https://ncbi.nlm.nih.gov/pubmed/20149249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-9-51
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