Central nervous system exposure of next generation quinoline methanols is reduced relative to mefloquine after intravenous dosing in mice

BACKGROUND: The clinical use of mefloquine (MQ) has declined due to dose-related neurological events. Next generation quinoline methanols (NGQMs) that do not accumulate in the central nervous system (CNS) to the same extent may have utility. In this study, CNS levels of NGQMs relative to MQ were mea...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Dow, Geoffrey S, Milner, Erin, Bathurst, Ian, Bhonsle, Jayendra, Caridha, Diana, Gardner, Sean, Gerena, Lucia, Kozar, Michael, Lanteri, Charlotte, Mannila, Anne, McCalmont, William, Moon, Jay, Read, Kevin D, Norval, Suzanne, Roncal, Norma, Shackleford, David M, Sousa, Jason, Steuten, Jessica, White, Karen L, Zeng, Qiang, Charman, Susan A
التنسيق: Artigo
اللغة:Inglês
منشور في: BioMed Central 2011
الموضوعات:
Research
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128011/
https://ncbi.nlm.nih.gov/pubmed/21645370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2875-10-150
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