The IDOL–UBE2D complex mediates sterol-dependent degradation of the LDL receptor

We previously identified the E3 ubiquitin ligase IDOL as a sterol-dependent regulator of the LDL receptor (LDLR). The molecular pathway underlying IDOL action, however, remains to be determined. Here we report the identification and biochemical and structural characterization of an E2–E3 ubiquitin l...

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Autors principals: Zhang, Li, Fairall, Louise, Goult, Benjamin T., Calkin, Anna C., Hong, Cynthia, Millard, Christopher J., Tontonoz, Peter, Schwabe, John W.R.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2011
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127428/
https://ncbi.nlm.nih.gov/pubmed/21685362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2056211
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