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FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors
The E3 ubiquitin ligase IDOL (inducible degrader of the LDL receptor) regulates LDL receptor (LDLR)-dependent cholesterol uptake, but its mechanism of action, including the molecular basis for its stringent specificity, is poorly understood. Here we show that IDOL uses a singular strategy among E3 l...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3250164/ https://ncbi.nlm.nih.gov/pubmed/22109552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1111589108 |
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