The Ubiquitin Ligase Itch Regulates Apoptosis by Targeting Thioredoxin-interacting Protein for Ubiquitin-dependent Degradation

Thioredoxin interacting protein (TXNIP) was originally characterized as an endogenous inhibitor of thioredoxin, a key regulator in cellular redox homeostasis. TXNIP is also known to play important roles in tumor growth and metastasis, glucose and lipid metabolism. TXNIP expression is induced by vari...

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Main Authors: Zhang, Pingzhao, Wang, Chenji, Gao, Kun, Wang, Dejie, Mao, Jun, An, Jian, Xu, Chen, Wu, Di, Yu, Hongxiu, Liu, Jun O., Yu, Long
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Protein Synthesis and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838308/
https://ncbi.nlm.nih.gov/pubmed/20068034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.063321
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