Ubiquitin Ligase Ufd2 Is Required for Efficient Degradation of Mps1 Kinase

Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, r...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Chang, van Dyk, Dewald, Choe, Vitnary, Yan, Jing, Majumder, Shubhra, Costanzo, Michael, Bao, Xin, Boone, Charles, Huo, Keke, Winey, Mark, Fisk, Harold, Andrews, Brenda, Rao, Hai
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2011
Ämnen:
Protein Synthesis and Degradation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243506/
https://ncbi.nlm.nih.gov/pubmed/22045814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286229
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