Ubiquitin Ligase Ufd2 Is Required for Efficient Degradation of Mps1 Kinase

Ufd2 is a U-box-containing ubiquitylation enzyme that promotes ubiquitin chain assembly on substrates. The physiological function of Ufd2 remains poorly understood. Here, we show that ubiquitylation and degradation of the cell cycle kinase Mps1, a known target of the anaphase-promoting complex E3, r...

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Main Authors: Liu, Chang, van Dyk, Dewald, Choe, Vitnary, Yan, Jing, Majumder, Shubhra, Costanzo, Michael, Bao, Xin, Boone, Charles, Huo, Keke, Winey, Mark, Fisk, Harold, Andrews, Brenda, Rao, Hai
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243506/
https://ncbi.nlm.nih.gov/pubmed/22045814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.286229
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