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SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development
Akt signaling is an important regulator of neural development, but the distinctive function of Akt isoforms in brain development presents a challenge. Here we show Siah1 as an ubiquitin ligase that preferentially interacts with Akt3 and facilitates ubiquitination and degradation of Akt3. Akt3 is enr...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6802513/ https://ncbi.nlm.nih.gov/pubmed/31471318 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009618 |
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