SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development

Akt signaling is an important regulator of neural development, but the distinctive function of Akt isoforms in brain development presents a challenge. Here we show Siah1 as an ubiquitin ligase that preferentially interacts with Akt3 and facilitates ubiquitination and degradation of Akt3. Akt3 is enr...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Ko, Hyo Rim, Jin, Eun-Ju, Lee, Sang Bae, Kim, Chung Kwon, Yun, Taegwan, Cho, Sung-Woo, Park, Kye Won, Ahn, Jee-Yin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6802513/
https://ncbi.nlm.nih.gov/pubmed/31471318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.009618
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