The IDOL–UBE2D complex mediates sterol-dependent degradation of the LDL receptor

We previously identified the E3 ubiquitin ligase IDOL as a sterol-dependent regulator of the LDL receptor (LDLR). The molecular pathway underlying IDOL action, however, remains to be determined. Here we report the identification and biochemical and structural characterization of an E2–E3 ubiquitin l...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Li, Fairall, Louise, Goult, Benjamin T., Calkin, Anna C., Hong, Cynthia, Millard, Christopher J., Tontonoz, Peter, Schwabe, John W.R.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2011
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127428/
https://ncbi.nlm.nih.gov/pubmed/21685362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2056211
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