The IDOL–UBE2D complex mediates sterol-dependent degradation of the LDL receptor

We previously identified the E3 ubiquitin ligase IDOL as a sterol-dependent regulator of the LDL receptor (LDLR). The molecular pathway underlying IDOL action, however, remains to be determined. Here we report the identification and biochemical and structural characterization of an E2–E3 ubiquitin l...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zhang, Li, Fairall, Louise, Goult, Benjamin T., Calkin, Anna C., Hong, Cynthia, Millard, Christopher J., Tontonoz, Peter, Schwabe, John W.R.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Cold Spring Harbor Laboratory Press 2011
विषय:
Research Paper
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127428/
https://ncbi.nlm.nih.gov/pubmed/21685362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.2056211
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