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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
The BH3-only proteins Bim and Bad bind to the antiapoptotic Bcl-2 proteins and induce apoptosis in wild-type cells and cells from either bax(−/−) or bak(−/−) animals. In contrast, constitutively active forms of Bim and Bad failed to induce apoptosis in bax(−/−)bak(−/−) cells. Expression of Bax resto...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2001
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312722/ https://ncbi.nlm.nih.gov/pubmed/11410528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.897601 |
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