BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak
The BH3-only proteins Bim and Bad bind to the antiapoptotic Bcl-2 proteins and induce apoptosis in wild-type cells and cells from either bax(−/−) or bak(−/−) animals. In contrast, constitutively active forms of Bim and Bad failed to induce apoptosis in bax(−/−)bak(−/−) cells. Expression of Bax resto...
Sábháilte in:
| Foilsithe in: | Genes Dev |
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| Príomhchruthaitheoirí: | , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
Cold Spring Harbor Laboratory Press
2001
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| Ábhair: | |
| Rochtain ar líne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312722/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11410528/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.897601 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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