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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

The BH3-only proteins Bim and Bad bind to the antiapoptotic Bcl-2 proteins and induce apoptosis in wild-type cells and cells from either bax(−/−) or bak(−/−) animals. In contrast, constitutively active forms of Bim and Bad failed to induce apoptosis in bax(−/−)bak(−/−) cells. Expression of Bax resto...

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Udgivet i:Genes Dev
Principais autores: Zong, Wei-Xing, Lindsten, Tullia, Ross, Andrea J., MacGregor, Grant R., Thompson, Craig B.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312722/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11410528/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.897601
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