The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4(+) T Cell Decline and High Viral Load during Acute Infection

An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals is needed to guide vaccine design and immunization strategies. Here we used a large panel of 44 HIV-1 envelope variants (subtypes A, B, and C) to evaluate the presence of broadly neutralizing antibodies in s...

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Bibliografiske detaljer
Main Authors: Gray, Elin S., Madiga, Maphuti C., Hermanus, Tandile, Moore, Penny L., Wibmer, Constantinos Kurt, Tumba, Nancy L., Werner, Lise, Mlisana, Koleka, Sibeko, Sengeziwe, Williamson, Carolyn, Abdool Karim, Salim S., Morris, Lynn
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126191/
https://ncbi.nlm.nih.gov/pubmed/21389135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00198-11
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