The Neutralization Breadth of HIV-1 Develops Incrementally over Four Years and Is Associated with CD4(+) T Cell Decline and High Viral Load during Acute Infection

An understanding of how broadly neutralizing activity develops in HIV-1-infected individuals is needed to guide vaccine design and immunization strategies. Here we used a large panel of 44 HIV-1 envelope variants (subtypes A, B, and C) to evaluate the presence of broadly neutralizing antibodies in s...

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Detalhes bibliográficos
Main Authors: Gray, Elin S., Madiga, Maphuti C., Hermanus, Tandile, Moore, Penny L., Wibmer, Constantinos Kurt, Tumba, Nancy L., Werner, Lise, Mlisana, Koleka, Sibeko, Sengeziwe, Williamson, Carolyn, Abdool Karim, Salim S., Morris, Lynn
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126191/
https://ncbi.nlm.nih.gov/pubmed/21389135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00198-11
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