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Role of the WWOX tumor suppressor gene in bone homeostasis and the pathogenesis of osteosarcoma

Osteosarcoma is the most common primary bone malignancy in children with unknown etiology and often with poor clinical outcome. In recent years, a critical role has emerged for the WW domain-containing oxidoreductase (WWOX) in osteosarcoma and bone biology. WWOX is a tumor suppressor that is deleted...

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Autors principals: Del Mare, Sara, Kurek, Kyle C, Stein, Gary S, Lian, Jane B, Aqeilan, Rami I
Format: Artigo
Idioma:Inglês
Publicat: e-Century Publishing Corporation 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124638/
https://ncbi.nlm.nih.gov/pubmed/21731849
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