Conditional inactivation of the mouse Wwox tumor suppressor gene recapitulates the null phenotype()

WW domain-containing oxidoreductase (WWOX) is highly conserved in both humans and murine. WWOX spans the second most common human chromosomal fragile site, FRA16D, and is commonly inactivated in multiple human cancers. Modeling WWOX inactivation in mice revealed a complex phenotype including postnat...

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Hauptverfasser: Abdeen, Suhaib K., Mare, Sara Del, Hussain, Sadeeq, Remaileh, Muhannad Abu, Salah, Zaidoun, Hagan, John, Rawahneh, Maysoon, Pu, Xin-an, Russell, Stacey, Stein, Janet L., Stein, Gary S., Lian, Jane B., Aqeilan, Rami I.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943428/
https://ncbi.nlm.nih.gov/pubmed/23254685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.24308
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