Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma (OS), an aggressive bone tumor with poor prognosis that often metastasizes to lung. On the basis of these observations, we examined the st...

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Autori principali: Kurek, Kyle, Del Mare, Sara, Salah, Zaidoun, Abdeen, Suhaib, Sadiq, Hussain, Lee, Sukhee, Gaudio, Eugenio, Zanesi, Nicola, Jones, Kevin B., DeYoung, Barry, Amir, Gail, Gebhardt, Mark, Warman, Matthew, Stein, Gary S., Stein, Janet L., Lian, Jane B., Aqeilan, Rami I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037996/
https://ncbi.nlm.nih.gov/pubmed/20530675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4602
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