Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression

The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor that is deleted or attenuated in most human tumors. Wwox-deficient mice develop osteosarcoma (OS), an aggressive bone tumor with poor prognosis that often metastasizes to lung. On the basis of these observations, we examined the st...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Kurek, Kyle, Del Mare, Sara, Salah, Zaidoun, Abdeen, Suhaib, Sadiq, Hussain, Lee, Sukhee, Gaudio, Eugenio, Zanesi, Nicola, Jones, Kevin B., DeYoung, Barry, Amir, Gail, Gebhardt, Mark, Warman, Matthew, Stein, Gary S., Stein, Janet L., Lian, Jane B., Aqeilan, Rami I.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3037996/
https://ncbi.nlm.nih.gov/pubmed/20530675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4602
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky