WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma

Osteosarcoma (OS) is a highly metastatic form of bone cancer in adolescents and young adults which is resistant to existing treatments. Development of an effective therapy has been hindered by very limited understanding of the mechanisms of osteosarcomagenesis. Here, we used genetically engineered m...

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Bibliographic Details
Published in:Cancer Res
Main Authors: Del Mare, Sara, Husanie, Hussam, Iancu, Ortal, Abu-Odeh, Mohammad, Evangelou, Konstantinos, Lovat, Francesca, Volinia, Stefano, Gordon, Jonathan, Amir, Gail, Stein, Janet, Stein, Gary S., Croce, Carlo M., Gorgoulis, Vassilis, Lian, Jane B., Aqeilan, Rami I.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146760/
https://ncbi.nlm.nih.gov/pubmed/27550453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0621
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