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WWOX guards genome stability by activating ATM

Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates w...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Hazan, Idit, Abu-Odeh, Mohammad, Hofmann, Thomas G, Aqeilan, Rami I
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4905350/
https://ncbi.nlm.nih.gov/pubmed/27308504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2015.1008288
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