WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response

Genomic instability is a hallmark of cancer. The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor spanning the common chromosomal fragile site FRA16D. Here, we report a direct role of WWOX in DNA damage response (DDR) and DNA repair. We show that Wwox deficiency results in reduced ac...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Abu-Odeh, Mohammad, Salah, Zaidoun, Herbel, Christoph, Hofmann, Thomas G., Aqeilan, Rami I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2014
Konular:
PNAS Plus
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4226089/
https://ncbi.nlm.nih.gov/pubmed/25331887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409252111
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