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WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response
Genomic instability is a hallmark of cancer. The WW domain-containing oxidoreductase (WWOX) is a tumor suppressor spanning the common chromosomal fragile site FRA16D. Here, we report a direct role of WWOX in DNA damage response (DDR) and DNA repair. We show that Wwox deficiency results in reduced ac...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4226089/ https://ncbi.nlm.nih.gov/pubmed/25331887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1409252111 |
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