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Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

The role of common fragile sites (CFSs) in cancer remains controversial. Two main views dominate the discussion: one suggests that CFS loci are hotspots of genomic instability leading to inactivation of genes encoded within them, while the other view proposes that CFSs are functional units and that...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Hazan, Idit, Hofmann, Thomas G., Aqeilan, Rami I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157955/
https://ncbi.nlm.nih.gov/pubmed/27977694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006436
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