WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma

Osteosarcoma (OS) is a highly metastatic form of bone cancer in adolescents and young adults which is resistant to existing treatments. Development of an effective therapy has been hindered by very limited understanding of the mechanisms of osteosarcomagenesis. Here, we used genetically engineered m...

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Pubblicato in:Cancer Res
Autori principali: Del Mare, Sara, Husanie, Hussam, Iancu, Ortal, Abu-Odeh, Mohammad, Evangelou, Konstantinos, Lovat, Francesca, Volinia, Stefano, Gordon, Jonathan, Amir, Gail, Stein, Janet, Stein, Gary S., Croce, Carlo M., Gorgoulis, Vassilis, Lian, Jane B., Aqeilan, Rami I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5146760/
https://ncbi.nlm.nih.gov/pubmed/27550453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-0621
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