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The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors. To investigate WWOX function in vivo, we examined Wwox-deficient (Wwox(-)(/)...

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Bibliografiske detaljer
Main Authors: Aqeilan, Rami I., Hassan, Mohammad Q., de Bruin, Alain, Hagan, John P., Volinia, Stefano, Palumbo, Titziana, Hussain, Sadiq, Lee, Suk-Hee, Gaur, Tripti, Stein, Gary S., Lian, Jane B., Croce, Carlo M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490770/
https://ncbi.nlm.nih.gov/pubmed/18487609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800855200
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