The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors. To investigate WWOX function in vivo, we examined Wwox-deficient (Wwox(-)(/)...

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Detalhes bibliográficos
Main Authors: Aqeilan, Rami I., Hassan, Mohammad Q., de Bruin, Alain, Hagan, John P., Volinia, Stefano, Palumbo, Titziana, Hussain, Sadiq, Lee, Suk-Hee, Gaur, Tripti, Stein, Gary S., Lian, Jane B., Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490770/
https://ncbi.nlm.nih.gov/pubmed/18487609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800855200
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