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The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism
The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors. To investigate WWOX function in vivo, we examined Wwox-deficient (Wwox(-)(/)...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2490770/ https://ncbi.nlm.nih.gov/pubmed/18487609 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800855200 |
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