Targeted Ablation of the WW Domain-Containing Oxidoreductase Tumor Suppressor Leads to Impaired Steroidogenesis

The WW domain-containing oxidoreductase (WWOX) gene encodes a 46-kDa tumor suppressor. The Wwox protein contains two N-terminal WW domains that interact with several transcriptional activators containing proline-tyrosine motifs and a central short-chain dehydrogenase/reductase domain that has been s...

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Detalhes bibliográficos
Main Authors: Aqeilan, Rami I., Hagan, John P., de Bruin, Alain, Rawahneh, Maysoon, Salah, Zaidoun, Gaudio, Eugenio, Siddiqui, Hasan, Volinia, Stefano, Alder, Hansjuerg, Lian, Jane B., Stein, Gary S., Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Endocrine Society 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654736/
https://ncbi.nlm.nih.gov/pubmed/18974271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1087
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