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The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism

The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors. To investigate WWOX function in vivo, we examined Wwox-deficient (Wwox(-)(/)...

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書誌詳細
主要な著者: Aqeilan, Rami I., Hassan, Mohammad Q., de Bruin, Alain, Hagan, John P., Volinia, Stefano, Palumbo, Titziana, Hussain, Sadiq, Lee, Suk-Hee, Gaur, Tripti, Stein, Gary S., Lian, Jane B., Croce, Carlo M.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2490770/
https://ncbi.nlm.nih.gov/pubmed/18487609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800855200
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