DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.

Nitrogen mustard alkylating agents react with isolated DNA in a sequence selective manner, and the substituent attached to the drug reactive group can impose a distinct sequence preference. It is not clear however to what extent the observed DNA sequence preferences are preserved in intact cells. Th...

Ausführliche Beschreibung

Bibliografische Detailangaben

Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Hartley, J A, Bingham, J P, Souhami, R L
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1992
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1620613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.12.3175
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!