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DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.
Nitrogen mustard alkylating agents react with isolated DNA in a sequence selective manner, and the substituent attached to the drug reactive group can impose a distinct sequence preference. It is not clear however to what extent the observed DNA sequence preferences are preserved in intact cells. Th...
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| Autors principals: | , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
1992
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312455/ https://ncbi.nlm.nih.gov/pubmed/1620613 |
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