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Stability of adriamycin-induced DNA adducts and interstrand crosslinks.

The stability of adriamycin-induced DNA adducts and interstrand crosslinks was measured at 37 degrees C by three independent procedures. The loss of [14C]-labelled adducts was described by two first-order decays with half-lives of 7.4 h (60% amplitude) and 39 h (40%). The loss of the drug chromophor...

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Dettagli Bibliografici
Autori principali: van Rosmalen, A, Cullinane, C, Cutts, S M, Phillips, D R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC306628/
https://ncbi.nlm.nih.gov/pubmed/7870589
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